Literature summary for 3.1.3.6 extracted from

Sopwith, W.F.; Debrabant, A.; Yamage, M.; Dwyer, D.M.; Bates, P.A.
Developmentally regulated expression of a cell surface class I nuclease in Leishmania mexicana (2002), Int. J. Parasitol., 32, 449-459.

Search for more literature for 3.1.3.6

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	surface membrane	Leishmania mexicana	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	the enzyme contains a metal cofactor Zn2+-binding domain	Leishmania mexicana

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
41670	-	x * 41670, calculation from nucleotide sequence	Leishmania mexicana

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Leishmania mexicana	the enzyme plays a critical role in purine salvage pathway during the rapid multiplicative expansion of the parasite population within its insect vector. Starvation of the parasite for purines results in the significant up-regulation of both the 3'-nucleotidase/nuclease mRNA and enzyme activity in promastigotes, but not in amastigotes	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Leishmania mexicana	Q9GNZ4	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
promastigote	stage-specific enzyme, being expressed by promastigote forms, but not by amastigotes	Leishmania mexicana	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3'-AMP + H2O	-	Leishmania mexicana	adenosine + phosphate	-	?
additional information	the enzyme plays a critical role in purine salvage pathway during the rapid multiplicative expansion of the parasite population within its insect vector. Starvation of the parasite for purines results in the significant up-regulation of both the 3'-nucleotidase/nuclease mRNA and enzyme activity in promastigotes, but not in amastigotes	Leishmania mexicana	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 41670, calculation from nucleotide sequence	Leishmania mexicana

Synonyms

Synonyms	Comment	Organism
3'-nucleotidase/nuclease	-	Leishmania mexicana

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Release 2023.1 (January 2023)